The TDI is an estimate of the amount of a substance in air, food, or drinking water that can be taken daily over a lifetime without significant health risks. These substances can be present as a result of the manufacturing process or they can arise from natural or environmental sources.
Uncertainty factor provides a margin of safety for allowable human exposure, derived from measurements regarding the reaction of the most sensitive animal species in order to estimate an NOAEL or a LOAEL for humans.
No observed adverse effect Level is an exposure level at which there are no statistically or biologically significant increases in the frequency or severity of adverse effects between the exposed population and its appropriate control; some effects may be produced at this level, but they are not considered as adverse, or as precursors to adverse effects.
Lowest observed adverse effect Level is the lowest level of a chemical stressor evaluated in a toxicity test which shows harmful effects on a plant or animal. While LOAELs and LOAECs are similar, they are not interchangeable. A LOAEL refers to a dose of a chemical that is ingested.
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