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Tolerable Daily Intake/Allowable Limit


The TDI is an estimate of the amount of a substance in air, food, or drinking water that can be taken daily over a lifetime without appreciable health risk. 
These substances can be present as a result of the manufacturing process or they can arise from natural or environmental sources. 


Uncertainty factor

provide a margin of safety for allowable human exposure, derived from measurements with regard to the reaction of the most sensitive animal species in order to estimate an NOAEL or a LOAEL for humans.


No observed adverse effect level

an exposure level at which there are no statistically or biologically significant increases in the frequency or severity of adverse effects between the exposed population and its appropriate control; some effects may be produced at this level, but they are not considered as adverse, or as precursors to adverse effects.


Lowest observed adverse effect level

lowest level of a chemical stressor evaluated in a toxicity test that shows harmful effects on a plant or animal. While LOAELs and LOAECs are similar, they are not interchangeable. A LOAEL refers to a dose of chemical that is ingested.

Approval and registration support of new drugs and medical devices

Approval and license renewals with regard to performance and safety

On time and up to date document availability for your projects


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